D Gregory Smith

Old Drugs, New HIV Treatment?

Filed By D Gregory Smith | August 24, 2010 12:30 PM | comments

Filed in: Living
Tags: Big Pharma, Cancer drugs and HIV, HIV treatment, HIV/AIDS

There's news on the HIV treatment front. From Science Daily:

hivmeds.jpgResearchers at the University of Minnesota Academic Health Center have identified two drugs, that, when combined, may serve as an effective treatment for HIV. The two drugs, decitabine and gemcitabine -- both FDA approved and currently used in pre-cancer and cancer therapy -- were found to eliminate HIV infection in the mouse model by causing the virus to mutate itself to death -- an outcome researchers dubbed "lethal mutagenesis."

"So?" you say. "What's the big deal?"

Well, grab your wigs and keys and let me tell you.

HIV is a devastating disease. It's notoriously sly, mutating quickly, frustrating researchers, physicians, patients, families and governments.

It's also big business.

It costs money to research new medications, treatments, vaccines and prevention strategies. It costs money to provide medications through ADAP. It costs money to treat the side-effects from treatment- you get the picture.

This is a landmark finding in HIV research because it is the first time this novel approach has been used to attack the deadly virus without causing toxic side effects. Because decitabine and gemcitabine are already FDA approved, researchers believe that if their research is effective in large animal models, it will be much easier to expedite the development of the drugs for human use.

This is significant because taking on the treatment (and possible cure) of HIV with an existing drug that companies are (probably) already making money on after already spending money on research is a no-brainer. Researching new HIV meds is prohibitively expensive.

You can bet your ass if this is a significant treatment for HIV, they're going to make money. And money is what drives this thing.

Read the full story here.

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Another important thing is that gemcitabine is available as a generic (i.e. much cheaper) drug, and decitabine (which is sold under the Dacogen brand by Eisai) will be also in a few years.

At the end of the release, it noted that scientists were working on ways to administer the drugs orally. What this means is that if it's shown in clinical trials to work as well on humans as it does on mice, and some company develops a pill that combines the drugs and gets it approved by the FDA, the company can still win patent protection and market exclusivity for it for several years before a generic becomes available.

However, if the injected versions of the drugs work as well, then a doctor could theoretically prescribe them in generic form to an HIV patient.

Just because they've already done the research on these meds doesn't mean that they aren't going to charge people for that research anyway. I grew up in a pharma town - those mansions don't pay for themselves!

If only we could have decently-priced medications like they do in other countries, but then Americans can't have nice things.

Whatever a drug company does end up charging, the amount of patent/marketing protection it would be able to get for a drug combining gemcitabine and decitabine would be somewhat limited because neither drug is what the FDA would call a "new chemical entity." So it wouldn't be long before a generic version became available.

And again, assuming studies show the drug works for people with HIV, both gemcitabine and decitabine would be available as generics by the time that happened. So, if those same studies show that injecting the drugs works just as well as swallowing them, then a doctor could simply prescribe the generics, even if the pill was the only one actually approved by the FDA to treat HIV.

... by causing the virus to mutate itself to death ...

This is clearly impossible ... otherwise, it would have already happened to Madonna.

THAT, AJ, made me laugh out loud... Thanks!

Apostle Shada Mishe | August 24, 2010 6:16 PM


is being proven by the more than 400 individuals who have taken a dose of 60 ml three times daily for 21 days. The result is that AMBUSH 'KILLS' the virus by causing the protein envelope to rupture and the viral particles are discarded by the white blood cells. AMBUSH is able to 'KILL' the virus that are 'hiding' in the lymph system by its 'natural radioactive' properties. This process allows the body to 'return to normal health' with a corresponding immunity to that or those strains of the virus.

What is AMBUSH ?
AMBUSH is a radioactive isotope of uranium that is found in the 'palm' plant of which there are more than 3000 species. When ingested, AMBUSH causes the body temperature in the trunk area to rise to about 102 degrees when the individual is sleeping. The preparation takes four hours per batch, which is then given to the individuals for consumption 60 ml three times daily for 21 days. AMBUSH is a herbal preparation in this form but it contains an active ingredient which is a 'NEW' crystalline substance, a drug from the 'palm plant' similarly to ASPIRIN originating from the willow tree bark

After 21 days on AMBUSH, ALL the individuals experienced a decrease in viral load to undetectable, an increase in cd4, increase in RBC, an improvement in general health such as more color to the face, decrease in Buffalo hump, an increase in gluteal muscles, a decrease to having no joint pains whereby individuals can bend to touch their toes, and walk up steps are but a few examples. There is also a dramatic increase in their sexual appetite beginning after the first week of therapy

In any plant concoction such as percolated 'tea', there are 30-40,000 compounds, whi ch would take the scientific community twenty years to isolate one particular ingredient if they knew what they were looking for. The LORD GOD has given me seven steps to isolate the active ingredient, which is soft and metallic in nature and has a carbon- uranium-sulfur-(classified)-phentolamine configuration or structure. This is similar to Federick Kekule and the discovery of the benzene ring where he dreamt the structure.

As an antiviral and 'natural radioactivity' producing agent, AMBUSH is also effective against leukemia, lupus and HPV. Here I am saying that I have 'GIVEN' AMBUSH in the same 'strength' and dosage to patients with leukemia, lupus and HPV. A 35 year old male with HIV found it difficult to impossible to urinate was put on 'green tea' and water while the doctors contemplated prostrate surgery. One of the doctors gave him my number , I sent him a supply of AMBUSH an d he has not been given any more ARV's, since taking AMBUSH 18 months ago, is in 'good' health and has expressed a willingness to be examined by HIV investigators like many others who have taken AMBUSH.

I have sent this 'IDEA' to most HIV research agencies, scientist of the field, universities, hospitals, clinics, politicians and news agencies to which it is REJECTED because the name of THE LORD GOD is mentioned. He has steered me scientifically through the processes such as which plant and how to produce the active ingredient. What are the odds of a Florida Pharmacist picking a plant would contain the CURE for HIV/AIDS ?
I have never charged any of the people for their supply of AMBUSH but a life saving has been spent on the project with NO renumeration from any sources because AMBUSH falls outside the walls of modern medicine and research.


My proposal is that I PROVE that AMBUSH CURES HIV/AIDS by giving it to a number of END-STAGE or DRUG-RESISTANT people and the scientific community watches their recovery. This proposal addresses the problem in that I have already outlaid the results to be obtained.

This IDEA is unconventional in that the scientific community has rejected AMBUSH because I say it is GOD given. Secondly if I wrote it according to certain standards, then it might be peer reviewed. However, THE LORD GOD has also shown me that there are five enzyme systems associated with the virus, reverse transcriptase, protease, fusion and two more of which causes the virus to be AIRBOURNE. This means that without DIVINE intervention mankind and ALL warm- blooded mammals will be extinct in a number of years.

The PROOF of what I am saying is found in scientific papers wherein it is found that when the protease cuts the viral strands, it cuts it at DIFFERENT lengths EVERY time, to which it should always be a valine at the end but is a different amino acid every time. This is why it is IMPOSSIBLE to produce a VACCINE.

Since this is NOT a hypothesis but there are about 400 individuals who have taken AMBUSH, here lies a vast area in which to check, recheck and confirm that AMBUSH CURES AIDS. Let it be mentioned that during the HIV reproductive cycle, reverse transcriptase converts viral RNA into DNA compatible to human genetic materials. Thus the human DNA has been 'hijacked' and since each person has a DIFFERENT DNA, then the new viral copy is unique to that person which shows that each individual has a DIFFERENT STRAIN of the virus. Consider two HIV positive people swapping viral strains and increasing its complexity with multiple partners.
It can also be proposed that they be revisited as proof that the strain or strains that they had were 'killed' at the time of taking AMBUSH considering that a person can catch as many different strains as there are people who are infected by HIV.
I am also willing to work with the scientific community in identifying those individuals who took AMBUSH and wish to be identified with this process notwithstanding that some are stigmatized while others are jubilant,

Once AMBUSH is verified as being able to accomplish that which is aforementioned then the next stage might be the natural and artificial synthesis of the substance.

Finally, if this is accepted or not, believed or not, THE LORD GOD always wins and this is the heavenly truth to which AMBUSH was divinely given to mankind for the CURE of HIV/AIDS and it will be here forever.

The WORLD is therefore COMPELLED to listen......sooner or later....your choice !!!!!

Apostle Shada Mishe.

[email protected]

Here is a video taped presentation that I gave at t he Martin Luther King library in Washington


Anyone? I don't know where to begin....

Normally we'd TOS it for SPAM, but the Apostle didn't actually leave links to buy a product or anything.

Do I think it works? Hell no.

Dr. John P. Ouderkirk, M.D. | August 25, 2010 11:37 AM

Having treated HIV for over 10 years now as an infectious diseases specialist, there are numerous stories of "cures" out there that just don't pan out. Patient treated with "standard-of- care" medications tolerate them extremely well and survive this potential devastating disease as long as they are compliant. (I'm also Board-Certified in Internal Medicine for those skeptics who say that my job depends upon having HIV patients live longer...).
There's even information on the internet trying to convince people that HIV doesn't even cause AIDS. So, in my daily work helping patients with HIV survive and do well, am I so stupid that I just believe everything I'm told about HIV from the research or am I a murderer, an accomplice to keeping people sick when there are all sorts of "cures" out there? Beware of these "cures" for HIV, cancer, etcetera, etcetera. These "pseudo-cures" are comprised of a multi-BILLION dollar industry, trying to fool you out of your money. MOST physicians are very intelligent and care about their patients physical, mental and overall well-being and went into the wrong field if they were in it just for the money.

Thank you for the eloquent reminder, Dr Ouderkirk.
I know my medical team cares about me- they go the extra mile all the time, and I never feel rushed in appointments.
If this isn't the case with you, dear readers, shop around if you're able. Excellent caring medical providers are out there. And you deserve it.

"it is the first time this novel approach has been used to attack the deadly virus without causing toxic side effects."

I believe this claim only applies to cell cultures and possibly mice. There could be a very big difference in large mammals. Furthermore, the human safety/tox data that we have on the two drugs is limited to cancer therapy, which is short term use. Many drugs have looked safe over the short haul but some toxicities accrue over the long haul and it is months if not years before we see a safety signal. Such was the case with Gilead's adefovir, which was originally developed to treat HIV but proved to be too liver toxic; it is successful in treating hepatitis B, but that is at much lower doses.

I'm not holding my breath on the mutagenesis concept becasue HIV integrates itself into human cellular DNA. Ribavirin is believeed to operate on the same principle and it was tried with HIV with only very modest success.